cystic fibrosis

noun

: a common, progressive hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

… children with cystic fibrosis are born with healthy lungs; only later do their lungs become plugged with mucus and incur infections.The Journal of the American Medical Association
Cystic fibrosis is the most common lethal inherited disorder in the United States. Approximately 30,000 people in this country have inherited two defective copies of the CF gene and thus the disease; approximately 1 in 20 Americans has just one copy of the gene and is a carrier of the disease.Joe Palca
abbreviation CF

Examples of cystic fibrosis in a Sentence

Recent Examples on the Web
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Judah, a 14-year-old boy who was diagnosed with cystic fibrosis at just two weeks old has spent his life in and out of the hospital undergoing daily treatments, regular doctor appointments and facing numerous health scares. Lizzie Hyman, People.com, 21 Nov. 2024 His daughter passed away from cystic fibrosis in 2022, the outlet reported. Saleen Martin, USA TODAY, 14 Nov. 2024 Diagnosed with cystic fibrosis at birth, Payne is currently undergoing treatment for cancer, which has made campaigning door to door difficult. Eliza Griswold, The New Yorker, 18 Oct. 2024 High risk babies include those born prematurely with chronic lung disease, those with cystic fibrosis, those who are severely immunocompromised and those of American Indian or Alaskan Native heritage. Omer Awan, Forbes, 3 Nov. 2024 See all Example Sentences for cystic fibrosis 

Word History

Etymology

Note: The name cystic fibrosis refers to the cysts and fibrous scar tissue that form in the pancreas of people with the disease. The term was introduced by the American pediatrician and pathologist Dorothy Hansine Andersen (1901-63) in "Cystic Fibrosis of the Pancreas and Its Relation to Celiac Disease: a Clinical and Pathological study," American Journal of Diseases of Children, vol. 56, no. 2 (August, 1938), pp. 344–99. A similar term was used two years earlier by the Swiss pediatrician Guido Fanconi, in "Das Coeliakiesyndrom bei angeborener Zystischer Pancreasfibromatose und Bronchiektasien" ("Celiac syndrome with congenital cystic fibromatosis [development of multiple fibromas] of the pancreas and bronchiectases"), (Wiener medizinische Wochenschrift, vol. 86 [1936], pp. 753-56).

First Known Use

1938, in the meaning defined above

Time Traveler
The first known use of cystic fibrosis was in 1938

Dictionary Entries Near cystic fibrosis

Cite this Entry

“Cystic fibrosis.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cystic%20fibrosis. Accessed 15 Dec. 2024.

Kids Definition

cystic fibrosis

noun
: an inherited disease marked by the buildup of thick sticky mucus chiefly in the lungs and pancreas leading to recurrent lung infections and digestive problems

Medical Definition

cystic fibrosis

noun
: a common, progressive, hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

called also fibrocystic disease of the pancreas, mucoviscidosis

abbreviation CF

More from Merriam-Webster on cystic fibrosis

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